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Scientific Publications

On this page, all publications originating from or in collaboration with IBC2 are listed. The list does not contain manuscripts which were published by an IBC2 member during a previous employment. For each individual group leader, a full publication record can be found on the respective group page.
Due to the entries in the PubMed database, until 2014 the search string only catches publications in which first or last author were IBC2-affiliated. Manuscripts published in journals not listed on PubMed are listed at the bottom of the page.

Publications from PubMed: 362

Klann K, Münch C. Unbiased translation proteomics upon cell stress. Mol Cell Oncol 2020. 7 (4) 1763150 Link


Klann K, Bojkova D, Tascher G, Ciesek S, Münch C, Cinatl J. Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication. Mol. Cell 2020. Link


Eck F, Phuyal S, Smith MD, Kaulich M, Wilkinson S, Farhan H, Behrends C. ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesis. J. Cell. Sci. 2020. 133 (18) Link


McLaughlin KM, Bechtel M, Bojkova D, Münch C, Ciesek S, Wass MN, Michaelis M, Cinatl J. COVID-19-Related Coagulopathy-Is Transferrin a Missing Link? Diagnostics (Basel) 2020. 10 (8) Link


Han Z, Angerer H, Bischoff I, Qin Y, Stegmann D, Tuz K, Fritz G, Juarez O, Fürst R, Lashley D, Nasiri HR. Concise Synthesis of 1,4-Benzoquinone-Based Natural Products as Mitochondrial Complex I Substrates and Substrate-Based Inhibitors. ChemMedChem 2020. Link


Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I. Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature 2020. Link


Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M, Dikic I. Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms. Cell Chem Biol 2020. Link


Cinque L, De Leonibus C, Iavazzo M, Krahmer N, Intartaglia D, Salierno FG, De Cegli R, Di Malta C, Svelto M, Lanzara C, Maddaluno M, Wanderlingh LG, Huebner AK, Cesana M, Bonn F, Polishchuk E, Hübner CA, Conte I, Dikic I, Mann M, Ballabio A, Sacco F, Grumati P, Settembre C. MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B. EMBO J. 2020. 39 (17) e105696 Link


Osthues T, Zimmer B, Rimola V, Klann K, Schilling K, Mathoor P, Angioni C, Weigert A, Geisslinger G, Münch C, Scholich K, Sisignano M. The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain. Cells 2020. 9 (7) Link


Voelcker G. Aldophosphamide-thiazolidine (NSC-613060) an oxazaphosphorine cytostatic that crosses the blood brain barrier. Anticancer Drugs 2020. Link


Kenny HC, Tascher G, Ziemianin A, Rudwill F, Zahariev A, Chery I, Gauquelin-Koch G, Barielle MP, Heer M, Blanc S, O'Gorman DJ, Bertile F. Effectiveness of Resistive Vibration Exercise and Whey Protein Supplementation Plus Alkaline Salt on the Skeletal Muscle Proteome Following 21 Days of Bed Rest in Healthy Males. J. Proteome Res. 2020. 19 (8) 3438-3451 Link


Scherr J, Tang Z, Küllmer M, Balser S, Scholz AS, Winter A, Parey K, Rittner A, Grininger M, Zickermann V, Rhinow D, Terfort A, Turchanin A. Smart Molecular Nanosheets for Advanced Preparation of Biological Samples in Electron Cryo-Microscopy. ACS Nano 2020. 14 (8) 9972-9978 Link


Keiten-Schmitz J, Wagner K, Piller T, Kaulich M, Alberti S, Müller S. The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules. Mol. Cell 2020. 79 (1) 54-67.e7 Link


Klann K, Münch C. Instrument Logic Increases Identifications during Mutliplexed Translatome Measurements. Anal. Chem. 2020. 92 (12) 8041-8045 Link


Madern JM, Kim RQ, Misra M, Dikic I, Zhang Y, Ovaa H, Codée JDC, Filippov DV, van der Heden van Noort GJ. Synthesis of Stable NAD Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitylating Enzyme SdeC. Chembiochem 2020. Link


Bojkova D, Klann K, Koch B, Widera M, Krause D, Ciesek S, Cinatl J, Münch C. Proteomics of SARS-CoV-2-infected host cells reveals therapy targets. Nature 2020. 583 (7816) 469-472 Link


Key J, Maletzko A, Kohli A, Gispert S, Torres-Odio S, Wittig I, Heidler J, Bárcena C, López-Otín C, Lei Y, West AP, Münch C, Auburger G. Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease. Neurogenetics 2020. 21 (3) 187-203 Link


Trembinski DJ, Bink DI, Theodorou K, Sommer J, Fischer A, van Bergen A, Kuo CC, Costa IG, Schürmann C, Leisegang MS, Brandes RP, Alekseeva T, Brill B, Wietelmann A, Johnson CN, Spring-Connell A, Kaulich M, Werfel S, Engelhardt S, Hirt MN, Yorgan K, Eschenhagen T, Kirchhof L, Hofmann P, Jaé N, Wittig I, Hamdani N, Bischof C, Krishnan J, Houtkooper RH, Dimmeler S, Boon RA. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Nat Commun 2020. 11 (1) 2039 Link


Bogucka K, Pompaiah M, Marini F, Binder H, Harms G, Kaulich M, Klein M, Michel C, Radsak MP, Rosigkeit S, Grimminger P, Schild H, Rajalingam K. ERK3/MAPK6 controls IL-8 production and chemotaxis. Elife 2020. 9 Link


Putyrski M, Vakhrusheva O, Bonn F, Guntur S, Vorobyov A, Brandts C, Dikic I, Ernst A. Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine. Front Cell Dev Biol 2020. 8 208 Link


Mayorca-Guiliani AE, Willacy O, Madsen CD, Rafaeva M, Heumüller SE, Bock F, Sengle G, Koch M, Imhof T, Zaucke F, Wagener R, Sasaki T, Erler JT, Reuten R. Author Correction: Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D. Nat Protoc 2020. 15 (6) 2140 Link


Engel AL, Lorenz NI, Klann K, Münch C, Depner C, Steinbach JP, Ronellenfitsch MW, Luger AL. Serine-dependent redox homeostasis regulates glioblastoma cell survival. Br. J. Cancer 2020. 122 (9) 1391-1398 Link


Tiku V, Tan MW, Dikic I. Mitochondrial Functions in Infection and Immunity. Trends Cell Biol. 2020. 30 (4) 263-275 Link


Kliza K, Husnjak K. Resolving the Complexity of Ubiquitin Networks. Front Mol Biosci 2020. 7 21 Link


Maddi K, Sam DK, Bonn F, Prgomet S, Tulowetzke E, Akutsu M, Lopez-Mosqueda J, Dikic I. Wss1 Promotes Replication Stress Tolerance by Degrading Histones. Cell Rep 2020. 30 (9) 3117-3126.e4 Link


Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Fischer T, Walz S, Schülein-Völk C, Eilers U, Ade CP, Calzado MA, Orian A, Maric HM, Münch C, Rosenfeldt M, Eilers M, Diefenbacher ME. Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells. EMBO Mol Med 2020. 12 (4) e11101 Link


Wiechmann S, Maisonneuve P, Grebbin BM, Hoffmeister M, Kaulich M, Clevers H, Rajalingam K, Kurinov I, Farin HF, Sicheri F, Ernst A. Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. J. Biol. Chem. 2020. 295 (14) 4526-4540 Link


Parey K, Wirth C, Vonck J, Zickermann V. Respiratory complex I - structure, mechanism and evolution. Curr. Opin. Struct. Biol. 2020. 63 1-9 Link


Voelcker G. Causes and possibilities to circumvent cyclophosphamide toxicity. Anticancer Drugs 2020. 31 (6) 617-622 Link


Biederstädt A, Hassan Z, Schneeweis C, Schick M, Schneider L, Muckenhuber A, Hong Y, Siegers G, Nilsson L, Wirth M, Dantes Z, Steiger K, Schunck K, Langston S, Lenhof HP, Coluccio A, Orben F, Slawska J, Scherger A, Saur D, Müller S, Rad R, Weichert W, Nilsson J, Reichert M, Schneider G, Keller U. SUMO pathway inhibition targets an aggressive pancreatic cancer subtype. Gut 2020. 69 (8) 1472-1482 Link


Keiten-Schmitz J, Schunck K, Müller S. SUMO Chains Rule on Chromatin Occupancy. Front Cell Dev Biol 2019. 7 343 Link


Hannig J, Schäfer H, Ackermann J, Hebel M, Schäfer T, Döring C, Hartmann S, Hansmann ML, Koch I. Bioinformatics analysis of whole slide images reveals significant neighborhood preferences of tumor cells in Hodgkin lymphoma. PLoS Comput. Biol. 2020. 16 (1) e1007516 Link


Mader J, Huber J, Bonn F, Dötsch V, Rogov VV, Bremm A. Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding. J. Biol. Chem. 2020. 295 (8) 2160-2174 Link


Karathanasis C, Medler J, Fricke F, Smith S, Malkusch S, Widera D, Fulda S, Wajant H, van Wijk SJL, Dikic I, Heilemann M. Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells. Sci Signal 2020. 13 (614) Link


Galemou Yoga E, Angerer H, Parey K, Zickermann V. Respiratory complex I - Mechanistic insights and advances in structure determination. Biochim Biophys Acta Bioenerg 2020. 1861 (3) 148153 Link


Parey K, Haapanen O, Sharma V, Köfeler H, Züllig T, Prinz S, Siegmund K, Wittig I, Mills DJ, Vonck J, Kühlbrandt W, Zickermann V. High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease. Sci Adv 2019. 5 (12) eaax9484 Link


Klann K, Tascher G, Münch C. Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α. Mol. Cell 2020. 77 (4) 913-925.e4 Link


Shin D, Mukherjee R, Liu Y, Gonzalez A, Bonn F, Liu Y, Rogov VV, Heinz M, Stolz A, Hummer G, Dötsch V, Luo ZQ, Bhogaraju S, Dikic I. Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB. Mol. Cell 2020. 77 (1) 164-179.e6 Link


Pohl C, Dikic I. Cellular quality control by the ubiquitin-proteasome system and autophagy. Science 2019. 366 (6467) 818-822 Link


Herhaus L, Bhaskara RM, Lystad AH, Gestal-Mato U, Covarrubias-Pinto A, Bonn F, Simonsen A, Hummer G, Dikic I. TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease. EMBO Rep. 2020. 21 (1) e48317 Link


Mayorca-Guiliani AE, Willacy O, Madsen CD, Rafaeva M, Elisabeth Heumüller S, Bock F, Sengle G, Koch M, Imhof T, Zaucke F, Wagener R, Sasaki T, Erler JT, Reuten R. Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D. Nat Protoc 2019. 14 (12) 3395-3425 Link


Hübner CA, Dikic I. ER-phagy and human diseases. Cell Death Differ. 2020. 27 (3) 833-842 Link


Dutta P, Odedra D, Pohl C. Planar Asymmetries in the Embryo Emerge by Differential Retention of aPARs at Cell-Cell Contacts. Front Cell Dev Biol 2019. 7 209 Link


Buchbender A, Mutter H, Sutandy FXR, Körtel N, Hänel H, Busch A, Ebersberger S, König J. Improved library preparation with the new iCLIP2 protocol. Methods 2020. 178 33-48 Link


Wagner K, Kunz K, Piller T, Tascher G, Hölper S, Stehmeier P, Keiten-Schmitz J, Schick M, Keller U, Müller S. The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics. Cell Rep 2019. 29 (2) 480-494.e5 Link


Pitzius S, Osterburg C, Gebel J, Tascher G, Schäfer B, Zhou H, Münch C, Dötsch V. TA*p63 and GTAp63 achieve tighter transcriptional regulation in quality control by converting an inhibitory element into an additional transactivation domain. Cell Death Dis 2019. 10 (10) 686 Link


Singh D, Odedra D, Dutta P, Pohl C. Mechanical stress induces a scalable switch in cortical flow polarization during cytokinesis. J. Cell. Sci. 2019. 132 (19) Link


Stolz A, Grumati P. The various shades of ER-phagy. FEBS J. 2019. 286 (23) 4642-4649 Link


Hoock SC, Ritter A, Steinhäuser K, Roth S, Behrends C, Oswald F, Solbach C, Louwen F, Kreis NN, Yuan J. RITA modulates cell migration and invasion by affecting focal adhesion dynamics. Mol Oncol 2019. 13 (10) 2121-2141 Link


Grozdanov V, Bousset L, Hoffmeister M, Bliederhaeuser C, Meier C, Madiona K, Pieri L, Kiechle M, McLean PJ, Kassubek J, Behrends C, Ludolph AC, Weishaupt JH, Melki R, Danzer KM. Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease. Ann. Neurol. 2019. 86 (4) 593-606 Link


Bhogaraju S, Bonn F, Mukherjee R, Adams M, Pfleiderer MM, Galej WP, Matkovic V, Lopez-Mosqueda J, Kalayil S, Shin D, Dikic I. Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation. Nature 2019. 572 (7769) 382-386 Link


Klimek C, Jahnke R, Wördehoff J, Kathage B, Stadel D, Behrends C, Hergovich A, Höhfeld J. The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy. Biochim Biophys Acta Mol Cell Res 2019. 1866 (10) 1556-1566 Link


Yuki KE, Marei H, Fiskin E, Eva MM, Gopal AA, Schwartzentruber JA, Majewski J, Cellier M, Mandl JN, Vidal SM, Malo D, Dikic I. CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection. Nat Microbiol 2019. 4 (9) 1516-1531 Link


Herhaus L, van den Bedem H, Tang S, Maslennikov I, Wakatsuki S, Dikic I, Rahighi S. Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains. J. Mol. Biol. 2019. 431 (17) 3146-3156 Link


Galemou Yoga E, Haapanen O, Wittig I, Siegmund K, Sharma V, Zickermann V. Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics. Biochim Biophys Acta Bioenerg 2019. 1860 (7) 573-581 Link


Bhaskara RM, Grumati P, Garcia-Pardo J, Kalayil S, Covarrubias-Pinto A, Chen W, Kudryashev M, Dikic I, Hummer G. Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy. Nat Commun 2019. 10 (1) 2370 Link


Scherr J, Neuhaus A, Parey K, Klusch N, Murphy BJ, Zickermann V, Kühlbrandt W, Terfort A, Rhinow D. Noncovalent Functionalization of Carbon Substrates with Hydrogels Improves Structural Analysis of Vitrified Proteins by Electron Cryo-Microscopy. ACS Nano 2019. 13 (6) 7185-7190 Link


Mukherjee R, Dikic I. NIPSNAP Beacons in Mitophagy. Dev. Cell 2019. 49 (4) 503-505 Link


Verma D, Kumar R, Pereira RS, Karantanou C, Zanetti C, Minciacchi VR, Fulzele K, Kunz K, Hoelper S, Zia-Chahabi S, Jabagi MJ, Emmerich J, Dray-Spira R, Kuhlee F, Hackmann K, Schroeck E, Wenzel P, Müller S, Filmann N, Fontenay M, Pajevic PD, Krause DS. Vitamin K antagonism impairs the bone marrow microenvironment and hematopoiesis. Blood 2019. 134 (3) 227-238 Link


Misra M, Dikic I. RNA binding to p62 impacts selective autophagy. Cell Res. 2019. 29 (7) 512-513 Link


Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, Güntert P, Dikic I, Kirkin V, Komatsu M, Dötsch V, Rogov VV. An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5. Autophagy 2020. 16 (2) 256-270 Link


Ivanova S, Polajnar M, Narbona-Perez AJ, Hernandez-Alvarez MI, Frager P, Slobodnyuk K, Plana N, Nebreda AR, Palacin M, Gomis RR, Behrends C, Zorzano A. Regulation of death receptor signaling by the autophagy protein TP53INP2. EMBO J. 2019. 38 (10) Link


Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M. Deubiquitinase USP10 regulates Notch signaling in the endothelium. Science 2019. 364 (6436) 188-193 Link


Tiku V, Dikic I. Autophagy without conjugation. Nat. Struct. Mol. Biol. 2019. 26 (4) 249-250 Link


Graab P, Bock C, Weiss K, Hirth A, Koller N, Braner M, Jung J, Loehr F, Tampé R, Behrends C, Abele R. Lysosomal targeting of the ABC transporter TAPL is determined by membrane-localized charged residues. J. Biol. Chem. 2019. 294 (18) 7308-7323 Link


Linder B, Wehle A, Hehlgans S, Bonn F, Dikic I, Rödel F, Seifert V, Kögel D. Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling. Cancers (Basel) 2019. 11 (3) Link


Voelcker G. Oxazaphosphorine cytostatics: from serendipity to rational drug design. Anticancer Drugs 2019. 30 (5) 435-440 Link


Kunz K, Müller S, Mendler L. Assays of SUMO protease/isopeptidase activity and function in mammalian cells and tissues. Meth. Enzymol. 2019. 618 389-410 Link


Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M. Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome. Elife 2019. 8 Link


Bencsik P, Kiss K, Ágg B, Baán JA, Ágoston G, Varga A, Gömöri K, Mendler L, Faragó N, Zvara Á, Sántha P, Puskás LG, Jancsó G, Ferdinandy P. Sensory Neuropathy Affects Cardiac miRNA Expression Network Targeting , , , and mRNAs. Int J Mol Sci 2019. 20 (4) Link


Tascher G, Burban A, Camus S, Plumel M, Chanon S, Le Guevel R, Shevchenko V, Van Dorsselaer A, Lefai E, Guguen-Guillouzo C, Bertile F. In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes. Cells 2019. 8 (2) Link


Manczyk N, Veggiani G, Gish GD, Yates BP, Ernst A, Sidhu SS, Sicheri F. Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif. Protein Sci. 2019. 28 (5) 848-856 Link


Chaikuad A, Koschade SE, Stolz A, Zivkovic K, Pohl C, Shaid S, Ren H, Lambert LJ, Cosford NDP, Brandts CH, Knapp S. Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). Biochem. J. 2019. 476 (5) 875-887 Link


Fottner M, Brunner AD, Bittl V, Horn-Ghetko D, Jussupow A, Kaila VRI, Bremm A, Lang K. Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase. Nat. Chem. Biol. 2019. 15 (3) 276-284 Link


Key J, Mueller AK, Gispert S, Matschke L, Wittig I, Corti O, Münch C, Decher N, Auburger G. Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons. Neurobiol. Dis. 2019. 127 114-130 Link


Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LT, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Münch C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L. Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury. Kidney Int. 2019. 95 (3) 540-562 Link


van Wijk SJ, Fulda S, Dikic I, Heilemann M. Visualizing ubiquitination in mammalian cells. EMBO Rep. 2019. 20 (2) Link


Juretschke T, Beli P, Dikic I. Quantitative Phosphoproteomics of Selective Autophagy Receptors. Methods Mol. Biol. 2019. 1880 691-701 Link


Bäckhed F, Bugianesi E, Christofk H, Dikic I, Gupta R, Mair WB, O'Neill LAJ, Ralser M, Sabatini DM, Tschöp M. The next decade of metabolism. Nat Metab 2019. 1 (1) 2-4 Link


Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, Fregno I, Raimondi A, Marazza A, Bruno G, Iavazzo M, Intartaglia D, Seczynska M, van Anken E, Conte I, De Matteis MA, Dikic I, Molinari M, Settembre C. A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex. EMBO J. 2019. 38 (2) Link


Nguyen TD, Shaid S, Vakhrusheva O, Koschade SE, Klann K, Thölken M, Baker F, Zhang J, Oellerich T, Sürün D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, Münch C, Dikic I, Brandts CH. Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Blood 2019. 133 (2) 168-179 Link


Dikic I. Open questions: why should we care about ER-phagy and ER remodelling? BMC Biol. 2018. 16 (1) 131 Link


Cabrera-Orefice A, Yoga EG, Wirth C, Siegmund K, Zwicker K, Guerrero-Castillo S, Zickermann V, Hunte C, Brandt U. Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps. Nat Commun 2018. 9 (1) 4500 Link


Herhaus L, Dikic I. Dimerization quality control via ubiquitylation. Science 2018. 362 (6411) 151-152 Link


Kenne E, Rasmuson J, Renné T, Vieira ML, Müller-Esterl W, Herwald H, Lindbom L. Neutrophils engage the kallikrein-kinin system to open up the endothelial barrier in acute inflammation. FASEB J. 2019. 33 (2) 2599-2609 Link


Parey K, Brandt U, Xie H, Mills DJ, Siegmund K, Vonck J, Kühlbrandt W, Zickermann V. Cryo-EM structure of respiratory complex I at work. Elife 2018. 7 Link


Bonn F, Maaß S, van Dijl JM. Enrichment of Cell Surface-Associated Proteins in Gram-Positive Bacteria by Biotinylation or Trypsin Shaving for Mass Spectrometry Analysis. Methods Mol. Biol. 2018. 1841 35-43 Link


Bonn F, Otto A. Protein Enrichment from Highly Dilute Samples with StrataClean. Methods Mol. Biol. 2018. 1841 11-18 Link


Gärtner A, Wagner K, Hölper S, Kunz K, Rodriguez MS, Müller S. Acetylation of SUMO2 at lysine 11 favors the formation of non-canonical SUMO chains. EMBO Rep. 2018. 19 (11) Link


Grumati P, Dikic I, Stolz A. ER-phagy at a glance. J. Cell. Sci. 2018. 131 (17) Link


Castagnaro S, Chrisam M, Cescon M, Braghetta P, Grumati P, Bonaldo P. Extracellular Collagen VI Has Prosurvival and Autophagy Instructive Properties in Mouse Fibroblasts. Front Physiol 2018. 9 1129 Link


Lang F, Khaghani S, Türk C, Wiederstein JL, Hölper S, Piller T, Nogara L, Blaauw B, Günther S, Müller S, Braun T, Krüger M. Single Muscle Fiber Proteomics Reveals Distinct Protein Changes in Slow and Fast Fibers during Muscle Atrophy. J. Proteome Res. 2018. 17 (10) 3333-3347 Link


Flach H, Krieg J, Hoffmeister M, Dietmann P, Reusch A, Wischmann L, Kernl B, Riegger R, Oess S, Kühl SJ. Nosip functions during vertebrate eye and cranial cartilage development. Dev. Dyn. 2018. 247 (9) 1070-1082 Link


Münch C. The different axes of the mammalian mitochondrial unfolded protein response. BMC Biol. 2018. 16 (1) 81 Link


Neuss S, Bartel Y, Born C, Weil S, Koch J, Behrends C, Hoffmeister M, Steinle A. Cellular Mechanisms Controlling Surfacing of AICL Glycoproteins, Cognate Ligands of the Activating NK Receptor NKp80. J. Immunol. 2018. 201 (4) 1275-1286 Link


Meyer N, Zielke S, Michaelis JB, Linder B, Warnsmann V, Rakel S, Osiewacz HD, Fulda S, Mittelbronn M, Münch C, Behrends C, Kögel D. AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. Autophagy 2018. 14 (10) 1693-1709 Link


Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR. Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis. Cell 2018. 174 (1) 88-101.e16 Link


Kalayil S, Bhogaraju S, Bonn F, Shin D, Liu Y, Gan N, Basquin J, Grumati P, Luo ZQ, Dikic I. Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination. Nature 2018. 557 (7707) 734-738 Link


Wiederstein JL, Nolte H, Günther S, Piller T, Baraldo M, Kostin S, Bloch W, Schindler N, Sandri M, Blaauw B, Braun T, Hölper S, Krüger M. Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown. Cell Rep 2018. 23 (5) 1342-1356 Link


Münch C, Dikic I. Publisher Correction: Hitchhiking on selective autophagy. Nat. Cell Biol. 2018. 20 (8) 990 Link


Zöller T, Wittenbrink M, Hoffmeister M, Steinle A. Cutting an NKG2D Ligand Short: Cellular Processing of the Peculiar Human NKG2D Ligand ULBP4. Front Immunol 2018. 9 620 Link


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Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort GJ, Filippov DV. A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins. Angew. Chem. Int. Ed. Engl. 2018. 57 (6) 1659-1662 Link


Varga ZV, Pipicz M, Baán JA, Baranyai T, Koncsos G, Leszek P, Kuśmierczyk M, Sánchez-Cabo F, García-Pavía P, Brenner GJ, Giricz Z, Csont T, Mendler L, Lara-Pezzi E, Pacher P, Ferdinandy P. Alternative Splicing of NOX4 in the Failing Human Heart. Front Physiol 2017. 8 935 Link


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Sairenji TJ, Ikezawa J, Kaneko R, Masuda S, Uchida K, Takanashi Y, Masuda H, Sairenji T, Amano I, Takatsuru Y, Sayama K, Haglund K, Dikic I, Koibuchi N, Shimokawa N. Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring. Proc. Natl. Acad. Sci. U.S.A. 2017. 114 (49) 13042-13047 Link


Le Guerroué F, Eck F, Jung J, Starzetz T, Mittelbronn M, Kaulich M, Behrends C. Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol. Cell 2017. 68 (4) 786-796.e6 Link


Newman AC, Kemp AJ, Drabsch Y, Behrends C, Wilkinson S. Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins. Nat Commun 2017. 8 (1) 1537 Link


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Ilina EI, Armento A, Sanchez LG, Reichlmeir M, Braun Y, Penski C, Capper D, Sahm F, Jennewein L, Harter PN, Zukunft S, Fleming I, Schulte D, Le Guerroué F, Behrends C, Ronellenfitsch MW, Naumann U, Mittelbronn M. Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux. Oncotarget 2017. 8 (40) 67567-67591 Link


Jung J, Behrends C. Protocol for Establishing a Multiplex Image-based Autophagy RNAi Screen in Cell Cultures. Bio Protoc 2017. 7 (17) 27982478 Link


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Polajnar M, Dietz MS, Heilemann M, Behrends C. Expanding the host cell ubiquitylation machinery targeting cytosolic . EMBO Rep. 2017. 18 (9) 1572-1585 Link


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Jung J, Behrends C. Multifaceted role of SMCR8 as autophagy regulator. Small GTPases 2020. 11 (1) 53-61 Link


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Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG. Structural and functional analysis of the GABARAP interaction motif (GIM). EMBO Rep. 2017. 18 (8) 1382-1396 Link


Grumati P, Morozzi G, Hölper S, Mari M, Harwardt MI, Yan R, Müller S, Reggiori F, Heilemann M, Dikic I. Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy. Elife 2017. 6 Link


Scherr J, Parey K, Klusch N, Murphy BJ, Balser S, Neuhaus A, Zickermann V, Kühlbrandt W, Terfort A, Rhinow D. Self-Perforated Hydrogel Nanomembranes Facilitate Structural Analysis of Proteins by Electron Cryo-Microscopy. ACS Nano 2017. 11 (6) 6467-6473 Link


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Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Mol. Cell 2017. 66 (4) 517-532.e9 Link


van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I. Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation. Nat Microbiol 2017. 2 17066 Link


Dikic I. Proteasomal and Autophagic Degradation Systems. Annu. Rev. Biochem. 2017. 86 193-224 Link


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Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch AK, Müller S, Dikic I, Mittelbronn M, Behrends C. Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Elife 2017. 6 Link


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Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H. The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function. EMBO J. 2017. 36 (3) 260-273 Link


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Tooze SA, Dikic I. Autophagy Captures the Nobel Prize. Cell 2016. 167 (6) 1433-1435 Link


Scheidel J, Amstein L, Ackermann J, Dikic I, Koch I. In Silico Knockout Studies of Xenophagic Capturing of Salmonella. PLoS Comput. Biol. 2016. 12 (12) e1005200 Link


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Lopez-Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic-Terzic I, Terzic J, Dikic I. SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. Elife 2016. 5 Link


Hoeller D, Dikic I. How the proteasome is degraded. Proc. Natl. Acad. Sci. U.S.A. 2016. 113 (47) 13266-13268 Link


Raman N, Weir E, Müller S. The AAA ATPase MDN1 Acts as a SUMO-Targeted Regulator in Mammalian Pre-ribosome Remodeling. Mol. Cell 2016. 64 (3) 607-615 Link


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Altmann C, Hardt S, Fischer C, Heidler J, Lim HY, Häussler A, Albuquerque B, Zimmer B, Möser C, Behrends C, Koentgen F, Wittig I, Schmidt MHH, Clement AM, Deller T, Tegeder I. Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy. Neurobiol. Dis. 2016. 96 294-311 Link


Castagnaro S, Pellegrini C, Pellegrini M, Chrisam M, Sabatelli P, Toni S, Grumati P, Ripamonti C, Pratelli L, Maraldi NM, Cocchi D, Righi V, Faldini C, Sandri M, Bonaldo P, Merlini L. Autophagy activation in COL6 myopathic patients by a low-protein-diet pilot trial. Autophagy 2016. 12 (12) 2484-2495 Link


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Mauthe M, Langereis M, Jung J, Zhou X, Jones A, Omta W, Tooze SA, Stork B, Paludan SR, Ahola T, Egan D, Behrends C, Mokry M, de Haan C, van Kuppeveld F, Reggiori F. An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication. J. Cell Biol. 2016. 214 (5) 619-35 Link


Teng B, Schroder P, Müller-Deile J, Schenk H, Staggs L, Tossidou I, Dikic I, Haller H, Schiffer M. CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes. Diabetes 2016. 65 (12) 3667-3679 Link


Weishaupt JH, Hyman T, Dikic I. Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Trends Mol Med 2016. 22 (9) 769-783 Link


Bionda T, Behrends C. Unveiling ubiquitinome rearrangements induced by Salmonella infection. Autophagy 2016. 12 (9) 1683-4 Link


Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK, Oegema K. 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. J. Cell Biol. 2016. 214 (2) 155-66 Link


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Genau HM, Behrends C. GABARAP proteins as scaffolds in localized TIAM1-RAC1 signaling. Mol Cell Oncol 2016. 3 (1) e1027440 Link


Brandes RP, Harenkamp S, Schürmann C, Josipovic I, Rashid B, Rezende F, Löwe O, Moll F, Epah J, Eresch J, Nayak A, Kopaliani I, Penski C, Mittelbronn M, Weissmann N, Schröder K. The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial Stalk Cell Phenotype. Arterioscler. Thromb. Vasc. Biol. 2016. 36 (8) 1558-65 Link


Fiskin E, Bionda T, Dikic I, Behrends C. Global Analysis of Host and Bacterial Ubiquitinome in Response to Salmonella Typhimurium Infection. Mol. Cell 2016. 62 (6) 967-981 Link


Bhogaraju S, Dikic I. Cell biology: Ubiquitination without E1 and E2 enzymes. Nature 2016. 533 (7601) 43-4 Link


Strecker V, Kadeer Z, Heidler J, Cruciat CM, Angerer H, Giese H, Pfeiffer K, Stuart RA, Wittig I. Supercomplex-associated Cox26 protein binds to cytochrome c oxidase. Biochim. Biophys. Acta 2016. 1863 (7 Pt A) 1643-52 Link


Suzuki N, Rohaim A, Kato R, Dikic I, Wakatsuki S, Kawasaki M. A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1. FEBS J. 2016. 283 (11) 2004-17 Link


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Baccarini M, Dikic I. Editorial overview: Cell regulation. Curr. Opin. Cell Biol. 2016. 39 iv-vi Link


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Maculins T, Fiskin E, Bhogaraju S, Dikic I. Bacteria-host relationship: ubiquitin ligases as weapons of invasion. Cell Res. 2016. 26 (4) 499-510 Link


Jennewein L, Ronellenfitsch MW, Antonietti P, Ilina EI, Jung J, Stadel D, Flohr LM, Zinke J, von Renesse J, Drott U, Baumgarten P, Braczynski AK, Penski C, Burger MC, Theurillat JP, Steinbach JP, Plate KH, Dikic I, Fulda S, Brandts C, Kögel D, Behrends C, Harter PN, Mittelbronn M. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget 2016. 7 (15) 20016-32 Link


Voelcker G. Enhancement of antitumor activity of the oxazaphosphorine cytostatic SUM-IAP by N-methylformamide. J. Cancer Res. Clin. Oncol. 2016. 142 (6) 1183-9 Link


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Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V. Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation. J. Biol. Chem. 2016. 291 (17) 9025-41 Link


Wirth C, Brandt U, Hunte C, Zickermann V. Structure and function of mitochondrial complex I. Biochim. Biophys. Acta 2016. 1857 (7) 902-14 Link


Rajalingam K, Dikic I. SnapShot: Expanding the Ubiquitin Code. Cell 2016. 164 (5) 1074-1074.e1 Link


Akutsu M, Dikic I, Bremm A. Ubiquitin chain diversity at a glance. J. Cell. Sci. 2016. 129 (5) 875-80 Link


Mora J, Schlemmer A, Wittig I, Richter F, Putyrski M, Frank AC, Han Y, Jung M, Ernst A, Weigert A, Brüne B. Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses. J Mol Cell Biol 2016. 8 (5) 426-438 Link


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Olma MH, Dikic I. Cullins getting undressed by the protein exchange factor Cand1. Cell 2013. 153 (1) 14-6 Link


Fiškin E, Dikic I. Parkin promotes cell survival via linear ubiquitination. EMBO J. 2013. 32 (8) 1072-4 Link


Crosetto N, Mitra A, Silva MJ, Bienko M, Dojer N, Wang Q, Karaca E, Chiarle R, Skrzypczak M, Ginalski K, Pasero P, Rowicka M, Dikic I. Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing. Nat. Methods 2013. 10 (4) 361-5 Link


van Wijk SJ, Fiskin E, Putyrski M, Pampaloni F, Hou J, Wild P, Kensche T, Grecco HE, Bastiaens P, Dikic I. Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells. Mol. Cell 2012. 47 (5) 797-809 Link


Oberoi-Khanuja TK, Rajalingam K. IAPs as E3 ligases of Rac1: shaping the move. Small GTPases . 3 (2) 131-6 Link


Kovacevic I, Hu J, Siehoff-Icking A, Opitz N, Griffin A, Perkins AC, Munn AL, Müller-Esterl W, Popp R, Fleming I, Jungblut B, Hoffmeister M, Oess S. The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development. EMBO J. 2012. 31 (15) 3309-22 Link


Shaid S, Brandts CH, Serve H, Dikic I. Ubiquitination and selective autophagy. Cell Death Differ. 2013. 20 (1) 21-30 Link


Oberoi-Khanuja TK, Karreman C, Larisch S, Rapp UR, Rajalingam K. Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration. J. Biol. Chem. 2012. 287 (34) 28445-55 Link


Kensche T, Tokunaga F, Ikeda F, Goto E, Iwai K, Dikic I. Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB. J. Biol. Chem. 2012. 287 (28) 23626-34 Link


Ullmann R, Chien CD, Avantaggiati ML, Muller S. An acetylation switch regulates SUMO-dependent protein interaction networks. Mol. Cell 2012. 46 (6) 759-70 Link


Rahighi S, Dikic I. Selectivity of the ubiquitin-binding modules. FEBS Lett. 2012. 586 (17) 2705-10 Link


Behrends C, Fulda S. Receptor proteins in selective autophagy. Int J Cell Biol 2012. 2012 673290 Link


Imre G, Heering J, Takeda AN, Husmann M, Thiede B, zu Heringdorf DM, Green DR, van der Goot FG, Sinha B, Dötsch V, Rajalingam K. Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis. EMBO J. 2012. 31 (11) 2615-28 Link


Husnjak K, Dikic I. Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions. Annu. Rev. Biochem. 2012. 81 291-322 Link


Dikic I. Ivan Dikic was trained as a medical doctor at the University of Zagreb, Croatia. Curr. Biol. 2012. 22 (3) R76-7 Link


Popovic D, Akutsu M, Novak I, Harper JW, Behrends C, Dikic I. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. Mol. Cell. Biol. 2012. 32 (9) 1733-44 Link


van Wijk SJ, Bienko M, Dikic I. Role of UbL family modifiers and their binding proteins in cell signaling. Methods Mol. Biol. 2012. 832 163-71 Link


Oberoi TK, Dogan T, Hocking JC, Scholz RP, Mooz J, Anderson CL, Karreman C, Meyer zu Heringdorf D, Schmidt G, Ruonala M, Namikawa K, Harms GS, Carpy A, Macek B, Köster RW, Rajalingam K. IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J. 2012. 31 (1) 14-28 Link


Imre G, Larisch S, Rajalingam K. Ripoptosome: a novel IAP-regulated cell death-signalling platform. J Mol Cell Biol 2011. 3 (6) 324-6 Link


van Wijk SJ, Müller S, Dikic I. Shared and unique properties of ubiquitin and SUMO interaction networks in DNA repair. Genes Dev. 2011. 25 (17) 1763-9 Link


Rajalingam K, Dikic I. Healthy ageing through regulated proteostasis. EMBO J. 2011. 30 (15) 2983-5 Link


Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, Brady NR, Richter B, Korac J, Waidmann O, Choudhary C, Dötsch V, Bumann D, Dikic I. Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science 2011. 333 (6039) 228-33 Link


Behrends C, Harper JW. Constructing and decoding unconventional ubiquitin chains. Nat. Struct. Mol. Biol. 2011. 18 (5) 520-8 Link


Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I. SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature 2011. 471 (7340) 637-41 Link


Rajalingam K, van der Goot FG. When cells and microbes meet in Krakow. EMBO Rep. 2011. 12 (3) 188-90 Link


McEwan DG, Dikic I. The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation. Trends Cell Biol. 2011. 21 (4) 195-201 Link


Ikeda F, Rahighi S, Wakatsuki S, Dikic I. Selective binding of linear ubiquitin chains to NEMO in NF-kappaB activation. Adv. Exp. Med. Biol. 2011. 691 107-14 Link


Åkesson P, Herwald H, Rasmussen M, HÅkansson K, Abrahamson M, Hasan AAK, Schmaier AH, Müller-Esterl W, Björck L. Streptococcal inhibitor of complement-mediated lysis (SIC): an anti-inflammatory virulence determinant. Microbiology (Reading) 2010. 156 (Pt 12) 3660-3668 Link


Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I. CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J. 2010. 29 (14) 2421-32 Link


Deribe YL, Pawson T, Dikic I. Post-translational modifications in signal integration. Nat. Struct. Mol. Biol. 2010. 17 (6) 666-72 Link


Dikic I, Schmidt MHH. Notch: Implications of endogenous inhibitors for therapy. Bioessays 2010. 32 (6) 481-487 Link


Dikic I, Johansen T, Kirkin V. Selective autophagy in cancer development and therapy. Cancer Res. 2010. 70 (9) 3431-4 Link


Bienko M, Green CM, Sabbioneda S, Crosetto N, Matic I, Hibbert RG, Begovic T, Niimi A, Mann M, Lehmann AR, Dikic I. Regulation of translesion synthesis DNA polymerase eta by monoubiquitination. Mol. Cell 2010. 37 (3) 396-407 Link


Wild P, Dikic I. Mitochondria get a Parkin' ticket. Nat. Cell Biol. 2010. 12 (2) 104-6 Link


Deribe YL, Wild P, Chandrashaker A, Curak J, Schmidt MHH, Kalaidzidis Y, Milutinovic N, Kratchmarova I, Buerkle L, Fetchko MJ, Schmidt P, Kittanakom S, Brown KR, Jurisica I, Blagoev B, Zerial M, Stagljar I, Dikic I. Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Sci Signal 2009. 2 (102) ra84 Link


Dikic I, Dötsch V. Ubiquitin linkages make a difference. Nat. Struct. Mol. Biol. 2009. 16 (12) 1209-10 Link


Dikic I, Wakatsuki S, Walters KJ. Ubiquitin-binding domains - from structures to functions. Nat. Rev. Mol. Cell Biol. 2009. 10 (10) 659-71 Link


Neumüller O, Hoffmeister M, Babica J, Prelle C, Gegenbauer K, Smolenski AP. Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets. Blood 2009. 114 (7) 1396-404 Link


Picuric S, Friedrich M, Oess S. Expression and purification of recombinant human EGFL7 protein. Protein Expr. Purif. 2009. 68 (1) 1-6 Link


Schmidt MHH, Bicker F, Nikolic I, Meister J, Babuke T, Picuric S, Müller-Esterl W, Plate KH, Dikic I. Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. Nat. Cell Biol. 2009. 11 (7) 873-80 Link


Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin in selective autophagy. Mol. Cell 2009. 34 (3) 259-69 Link


Kirkin V, Lamark T, Johansen T, Dikic I. NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets. Autophagy 2009. 5 (5) 732-3 Link


Dikic I. Journal club. A new ubiquitin chain, a new signal. Nat. Rev. Mol. Cell Biol. 2009. 10 (5) 306 Link


Grabbe C, Dikic I. Functional roles of ubiquitin-like domain (ULD) and ubiquitin-binding domain (UBD) containing proteins. Chem. Rev. 2009. 109 (4) 1481-94 Link


Kirkin V, Lamark T, Sou YS, Bjørkøy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Øvervatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol. Cell 2009. 33 (4) 505-16 Link


Grabbe C, Dikic I. Cell biology. Going global on ubiquitin. Science 2008. 322 (5903) 872-3 Link


Wiesenthal A, Hoffmeister M, Siddique M, Kovacevic I, Oess S, Müller-Esterl W, Siehoff-Icking A. NOSTRINbeta--a shortened NOSTRIN variant with a role in transcriptional regulation. Traffic 2009. 10 (1) 26-34 Link


Crosetto N, Bienko M, Hibbert RG, Perica T, Ambrogio C, Kensche T, Hofmann K, Sixma TK, Dikic I. Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. J. Biol. Chem. 2008. 283 (50) 35173-85 Link


Beli P, Mascheroni D, Xu D, Innocenti M. WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2. Nat. Cell Biol. 2008. 10 (7) 849-57 Link


Ikeda F, Dikic I. Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series. EMBO Rep. 2008. 9 (6) 536-42 Link


Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, Hofmann K, Walters KJ, Finley D, Dikic I. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 2008. 453 (7194) 481-8 Link


Wagner S, Carpentier I, Rogov V, Kreike M, Ikeda F, Löhr F, Wu CJ, Ashwell JD, Dötsch V, Dikic I, Beyaert R. Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. Oncogene 2008. 27 (26) 3739-45 Link


Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP. Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets. J. Biol. Chem. 2008. 283 (4) 2297-306 Link


Raguz J, Wagner S, Dikic I, Hoeller D. Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases. FEBS Lett. 2007. 581 (24) 4767-72 Link


Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dötsch V, Dikic I. Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J. 2007. 26 (14) 3451-62 Link


Hoeller D, Hecker CM, Wagner S, Rogov V, Dötsch V, Dikic I. E3-independent monoubiquitination of ubiquitin-binding proteins. Mol. Cell 2007. 26 (6) 891-8 Link


Dikic I, Schmidt MHH. Malfunctions within the Cbl interactome uncouple receptor tyrosine kinases from destructive transport. Eur. J. Cell Biol. 2007. 86 (9) 505-12 Link


Babuke T, Tikkanen R. Dissecting the molecular function of reggie/flotillin proteins. Eur. J. Cell Biol. 2007. 86 (9) 525-32 Link


Fernow I, Icking A, Tikkanen R. Reggie-1 and reggie-2 localize in non-caveolar rafts in epithelial cells: cellular localization is not dependent on the expression of caveolin proteins. Eur. J. Cell Biol. 2007. 86 (6) 345-52 Link


de Oliveira SK, Hoffmeister M, Gambaryan S, Müller-Esterl W, Guimaraes JA, Smolenski AP. Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor. J. Biol. Chem. 2007. 282 (18) 13656-63 Link


Icking A, Amaddii M, Ruonala M, Höning S, Tikkanen R. Polarized transport of Alzheimer amyloid precursor protein is mediated by adaptor protein complex AP1-1B. Traffic 2007. 8 (3) 285-96 Link


Kirkin V, Dikic I. Role of ubiquitin- and Ubl-binding proteins in cell signaling. Curr. Opin. Cell Biol. 2007. 19 (2) 199-205 Link


Neumann-Giesen C, Fernow I, Amaddii M, Tikkanen R. Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton. J. Cell. Sci. 2007. 120 (Pt 3) 395-406 Link


Schmidt MHH, Dikic I. Ubiquitin and NEDD8: brothers in arms. Sci. STKE 2006. 2006 (362) .pe50 Link


Dikic I, Crosetto N, Calatroni S, Bernasconi P. Targeting ubiquitin in cancers. Eur. J. Cancer 2006. 42 (18) 3095-102 Link


Hoeller D, Hecker CM, Dikic I. Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nat. Rev. Cancer 2006. 6 (10) 776-88 Link


Schilling K, Opitz N, Wiesenthal A, Oess S, Tikkanen R, Müller-Esterl W, Icking A. Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. Mol. Biol. Cell 2006. 17 (9) 3870-80 Link


Oess S, Icking A, Fulton D, Govers R, Müller-Esterl W. Subcellular targeting and trafficking of nitric oxide synthases. Biochem. J. 2006. 396 (3) 401-9 Link


Ikeda F, Dikic I. CYLD in ubiquitin signaling and tumor pathogenesis. Cell 2006. 125 (4) 643-5 Link


Hecker CM, Rabiller M, Haglund K, Bayer P, Dikic I. Specification of SUMO1- and SUMO2-interacting motifs. J. Biol. Chem. 2006. 281 (23) 16117-27 Link


Hoeller D, Crosetto N, Blagoev B, Raiborg C, Tikkanen R, Wagner S, Kowanetz K, Breitling R, Mann M, Stenmark H, Dikic I. Regulation of ubiquitin-binding proteins by monoubiquitination. Nat. Cell Biol. 2006. 8 (2) 163-9 Link


Schmidt MHH, Husnjak K, Szymkiewicz I, Haglund K, Dikic I. Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix. Oncogene 2006. 25 (21) 3071-8 Link


Icking A, Schilling K, Wiesenthal A, Opitz N, Müller-Esterl W. FCH/Cdc15 domain determines distinct subcellular localization of NOSTRIN. FEBS Lett. 2006. 580 (1) 223-8 Link


Bienko M, Green CM, Crosetto N, Rudolf F, Zapart G, Coull B, Kannouche P, Wider G, Peter M, Lehmann AR, Hofmann K, Dikic I. Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science 2005. 310 (5755) 1821-4 Link


Icking A, Matt S, Opitz N, Wiesenthal A, Müller-Esterl W, Schilling K. NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. J. Cell. Sci. 2005. 118 (Pt 21) 5059-69 Link


Schmidt MHH, Dikic I. The Cbl interactome and its functions. Nat. Rev. Mol. Cell Biol. 2005. 6 (12) 907-18 Link


Haglund K, Dikic I. Ubiquitylation and cell signaling. EMBO J. 2005. 24 (19) 3353-9 Link


Schleicher M, Brundin F, Gross S, Müller-Esterl W, Oess S. Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton. Mol. Cell. Biol. 2005. 25 (18) 8251-8 Link


Meurer S, Pioch S, Gross S, Müller-Esterl W. Reactive oxygen species induce tyrosine phosphorylation of and Src kinase recruitment to NO-sensitive guanylyl cyclase. J. Biol. Chem. 2005. 280 (39) 33149-56 Link


Haglund K, Schmidt MHH, Wong ES, Guy GR, Dikic I. Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. EMBO Rep. 2005. 6 (7) 635-41 Link


Crosetto N, Tikkanen R, Dikic I. Oncogenic breakdowns in endocytic adaptor proteins. FEBS Lett. 2005. 579 (15) 3231-8 Link


Hoeller D, Volarevic S, Dikic I. Compartmentalization of growth factor receptor signalling. Curr. Opin. Cell Biol. 2005. 17 (2) 107-11 Link


Danielewski O, Schultess J, Smolenski A. The NO/cGMP pathway inhibits Rap 1 activation in human platelets via cGMP-dependent protein kinase I. Thromb. Haemost. 2005. 93 (2) 319-25 Link


Schultess J, Danielewski O, Smolenski AP. Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets. Blood 2005. 105 (8) 3185-92 Link


Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S. AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase. J. Biol. Chem. 2004. 279 (47) 49346-54 Link


Szymkiewicz I, Shupliakov O, Dikic I. Cargo- and compartment-selective endocytic scaffold proteins. Biochem. J. 2004. 383 (Pt 1) 1-11 Link


Dikic I. ALIX-ing phospholipids with endosome biogenesis. Bioessays 2004. 26 (6) 604-7 Link


Kowanetz K, Crosetto N, Haglund K, Schmidt MHH, Heldin CH, Dikic I. Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. J. Biol. Chem. 2004. 279 (31) 32786-95 Link


Szymkiewicz I, Destaing O, Jurdic P, Dikic I. SH3P2 in complex with Cbl and Src. FEBS Lett. 2004. 565 (1-3) 33-8 Link


Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I. Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. J. Cell. Sci. 2004. 117 (Pt 12) 2557-68 Link


Kowanetz K, Husnjak K, Höller D, Kowanetz M, Soubeyran P, Hirsch D, Schmidt MHH, Pavelic K, De Camilli P, Randazzo PA, Dikic I. CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. Mol. Biol. Cell 2004. 15 (7) 3155-66 Link


Smolenski A, Schultess J, Danielewski O, Garcia Arguinzonis MI, Thalheimer P, Kneitz S, Walter U, Lohmann SM. Quantitative analysis of the cardiac fibroblast transcriptome-implications for NO/cGMP signaling. Genomics 2004. 83 (4) 577-87 Link


Höller D, Dikic I. Receptor endocytosis via ubiquitin-dependent and -independent pathways. Biochem. Pharmacol. 2004. 67 (6) 1013-7 Link


Dikic I. Mechanisms controlling EGF receptor endocytosis and degradation. Biochem. Soc. Trans. 2003. 31 (Pt 6) 1178-81 Link


Haglund K, Di Fiore PP, Dikic I. Distinct monoubiquitin signals in receptor endocytosis. Trends Biochem. Sci. 2003. 28 (11) 598-603 Link


Neumann-Giesen C, Falkenbach B, Beicht P, Claasen S, Lüers G, Stuermer CA, Herzog V, Tikkanen R. Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression. Biochem. J. 2004. 378 (Pt 2) 509-18 Link


Dikic I, Szymkiewicz I, Soubeyran P. Cbl signaling networks in the regulation of cell function. Cell. Mol. Life Sci. 2003. 60 (9) 1805-27 Link


Kowanetz K, Szymkiewicz I, Haglund K, Kowanetz M, Husnjak K, Taylor JD, Soubeyran P, Engstrom U, Ladbury JE, Dikic I. Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors. J. Biol. Chem. 2003. 278 (41) 39735-46 Link


Zimmermann K, Opitz N, Dedio J, Renne C, Muller-Esterl W, Oess S. NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. U.S.A. 2002. 99 (26) 17167-72 Link


Piiper A, Dikic I, Lutz MP, Leser J, Kronenberger B, Elez R, Cramer H, Müller-Esterl W, Zeuzem S. Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells. J. Biol. Chem. 2002. 277 (46) 43623-30 Link


Renné T, Gailani D, Meijers JC, Müller-Esterl W. Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein. J. Biol. Chem. 2002. 277 (7) 4892-9 Link


Mailänder J, Müller-Esterl W, Dedio J. Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1. FEBS Lett. 2001. 507 (3) 331-5 Link


Cramer H, Schmenger K, Heinrich K, Horstmeyer A, Böning H, Breit A, Piiper A, Lundstrom K, Müller-Esterl W, Schroeder C. Coupling of endothelin receptors to the ERK/MAP kinase pathway. Roles of palmitoylation and G(alpha)q. Eur. J. Biochem. 2001. 268 (20) 5449-59 Link


Renné T, Müller-Esterl W. Cell surface-associated chondroitin sulfate proteoglycans bind contact phase factor H-kininogen. FEBS Lett. 2001. 500 (1-2) 36-40 Link


Renné T, Dedio J, David G, Müller-Esterl W. High molecular weight kininogen utilizes heparan sulfate proteoglycans for accumulation on endothelial cells. J. Biol. Chem. 2000. 275 (43) 33688-96 Link


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Voelcker G. Enzyme Catalyzed Decomposition of 4-Hydroxycyclophosphamide  The Open Conference Proceedings Journal, 2017. Link 

Voelcker G. Oxazaphosphorine cytostatics: A good way to create better is to study old oxazaphosphorines  Integrative Cancer Science and Therapeutics, 2017. Link 

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Zickermann V. Structure and Function of Respiratory Complex I. In Mechanisms of Primary Energy Transduction in Biology. M.Wikstrom, editor. RSC Publishing,  Cambridge. 2017.  60-80; DOI 10.1039/9781788010405 Link